PUBLICATIONS

van der Goot AT, Pearce MMP, Leto DE, Shaler TA and Kopito RR (2018) Redundant and antagonistic roles of XTP3B and OS9 in decoding glycan and non-glycan degrons in ER-associated degradation. Mol Cell 70(3): 516-30 (PMID: 29706535)

Donnelly KM and Pearce MMP (2018) Monitoring cell-to-cell transmission of prion-like protein aggregates in Drosophila melanogaster. J Vis Exp 133 (PMID: 29578503)

Pearce MMP (2017) Prion-like transmission of pathogenic protein aggregates in genetic models of neurodegenerative disease. Curr Opin Genet Dev 44:149-155 (PMID: 28441621)

Pearce MMP and Kopito RR (2017) Prion-like characteristics of polyglutamine-containing proteins. Cold Spring Harb Perspect Med pii: a024257 (PMID: 28096245)

 

Pearce MMP, Spartz EJ, Hong W, Luo L and Kopito RR (2015) Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in Drosophila brains. Nat Commun 6:6768 (PMID: 25866135)

            *highlighted as "Highly Cited HD Research" in 2015 by Huntington Study Group (HD Insights Vol. 16)

Tyler RE, Pearce MMP, Shaler TA, Olzmann JA, Greenblatt EG and Kopito RR (2012) Unassembled CD147 is an endogenous ER-associated degradation substrate. Mol Biol Cell 23(24): 4668-78 (PMID: 23097496)

 

Tsai YC, Leichner GS, Pearce MMP, Wilson GL, Wojcikiewicz RJH, Roitelman J and Weissman AM (2012) Differential regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and Insig-1 by enzymes of the ubiquitin-proteasome system. Mol Biol Cell 23(23): 4484-94 (PMID: 23087214)

 

Trevino RS, Lauckner JE, Sourigues Y, Pearce MMP, Bousset L, Melki R and Kopito RR (2012) Fibrillar structure and charge determine the interaction of polyglutamine protein aggregates with the cell surface. J Biol Chem 287(35): 29722-8 (PMID: 22753412)

 

Lu JP, Wang Y, Sliter DA, Pearce MMP and Wojcikiewicz RJH (2011) RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation. J Biol Chem 286(27): 24426-33 (PMID: 21610068)

 

Wang Y, Pearce MMP, Sliter DA, Olzmann JA, Christianson JC, Kopito RR, Boeckmann S, Gagen C, Leichner GS, Roitelman J and Wojcikiewicz RJH (2009) SPFH1 and 2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells. Biochim Biophys Acta 1793(11): 1710-8 (PMID: 19751772)

 

Wojcikiewicz RJH, Pearce MMP, Sliter DA, Wang Y (2009) When worlds collide: IP3 receptors and the ERAD pathway. Cell Calcium 46: 147-153 (PMID: 19709743)

 

Pearce MMP, Wormer D, Wilkens S and Wojcikiewicz RJH (2009) An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of activated inositol 1,4,5-trisphosphate receptors. J Biol Chem 284(16): 10433-45 (PMID: 19240031)

 

Pearce MMP, Wang Y, Kelley GG and Wojcikiewicz RJH (2007) SPFH2 mediates the endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors and other substrates in mammalian cells. J Biol Chem 282(28): 20104-15 (PMID: 17502376)

 

Alzayady K, Panning MM, Kelley GG and Wojcikiewicz RJH (2005) Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors. J Biol Chem 280(41): 34530-7 (PMID: 16103111)

 

Panning MM and Gilbert DM (2005) Spatio-temporal organization of DNA replication in murine embryonic stem, primary and immortalized cells. J Cell Biochem 95(1): 74-82 (PMID: 15723284)

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